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Wiebke Arlt Selected Research

Prostatic Neoplasms (Prostate Cancer)

12/2023Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites.
1/2022Abiraterone switches castration-resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling.
1/202111-Ketotestosterone is the predominant active androgen in prostate cancer patients after castration.
1/2021Validation of circulating steroid hormone measurements across different matrices by liquid chromatography-tandem mass spectrometry.
8/2019Assessment of the Safety of Glucocorticoid Regimens in Combination With Abiraterone Acetate for Metastatic Castration-Resistant Prostate Cancer: A Randomized, Open-label Phase 2 Study.
11/2017Circulating steroid hormone variations throughout different stages of prostate cancer.
1/2017A new dawn for androgens: Novel lessons from 11-oxygenated C19 steroids.
1/2016The Early Effects of Rapid Androgen Deprivation on Human Prostate Cancer.
12/2013Strategies for managing ACTH dependent mineralocorticoid excess induced by abiraterone.
5/2012Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.
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Wiebke Arlt Research Topics

Disease

35Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal)
01/2023 - 06/2004
26Neoplasms (Cancer)
05/2024 - 08/2010
25Adrenal Insufficiency (Adrenal Gland Hypofunction)
11/2023 - 09/2002
18Hypertension (High Blood Pressure)
05/2024 - 05/2010
17Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
07/2023 - 06/2003
13Insulin Resistance
10/2019 - 08/2011
12Adenoma (Adenomas)
05/2024 - 08/2016
12Adrenocortical Carcinoma
03/2024 - 01/2011
12Addison Disease (Addison's Disease)
03/2021 - 05/2002
11Prostatic Neoplasms (Prostate Cancer)
12/2023 - 02/2012
9Type 2 Diabetes Mellitus (MODY)
04/2024 - 08/2016
9Cushing Syndrome
07/2023 - 02/2015
8Adrenal incidentaloma
10/2023 - 12/2011
8Infections
01/2023 - 10/2009
8Congenital adrenal hyperplasia due to 21 hydroxylase deficiency
01/2021 - 02/2007
8Virilism (Virilization)
01/2020 - 08/2004
7Hyperaldosteronism (Conn Syndrome)
05/2024 - 04/2017
7Obesity
01/2021 - 11/2004
7Sepsis (Septicemia)
01/2020 - 07/2006
7Antley-Bixler Syndrome Phenotype
12/2010 - 03/2004
6Wounds and Injuries (Trauma)
03/2023 - 07/2006
6Critical Illness (Critically Ill)
01/2018 - 06/2008
6Disorders of Sex Development (Intersexuality)
09/2014 - 06/2004
5COVID-19
01/2024 - 07/2020
5Non-alcoholic Fatty Liver Disease
01/2024 - 09/2017
5Pheochromocytoma
07/2023 - 01/2016
5Hyperandrogenism
01/2021 - 06/2003
5Cortisone reductase deficiency
08/2011 - 08/2003
4Neoplasm Metastasis (Metastasis)
07/2023 - 08/2016
4Inflammation (Inflammations)
01/2021 - 01/2008
4Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
01/2021 - 01/2019
4Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
12/2017 - 01/2008
4Septic Shock (Toxic Shock Syndrome)
12/2017 - 07/2006
4Hypogonadism (Hypergonadotropic Hypogonadism)
09/2017 - 06/2010
3Dyslipidemias (Dyslipidemia)
10/2023 - 12/2016
3Paraganglioma (Paragangliomas)
10/2022 - 03/2013
3Anovulation
05/2021 - 05/2009
3Hyperplasia
01/2021 - 04/2017
3Metabolic Diseases (Metabolic Disease)
01/2020 - 09/2017
3Hypopituitarism (Sheehan's Syndrome)
11/2015 - 08/2003
2Menstruation Disturbances
12/2021 - 11/2017
2Cardiovascular Diseases (Cardiovascular Disease)
05/2021 - 09/2017
2Breast Neoplasms (Breast Cancer)
01/2021 - 03/2019
2Overweight
01/2021 - 01/2019
2Osteoporosis
10/2020 - 04/2017
2Fever (Fevers)
07/2020 - 04/2013
2Hypokalemia
08/2019 - 02/2012
2Diabetes Mellitus
01/2019 - 12/2016

Drug/Important Bio-Agent (IBA)

62AndrogensIBA
12/2023 - 09/2002
47SteroidsIBA
05/2024 - 06/2004
46Hydrocortisone (Cortisol)FDA LinkGeneric
11/2023 - 08/2003
44GlucocorticoidsIBA
11/2023 - 09/2002
17Oxidoreductases (Dehydrogenase)IBA
01/2020 - 03/2004
15Hormones (Hormone)IBA
07/2023 - 02/2002
15Dehydroepiandrosterone (DHEA)IBA
01/2021 - 05/2002
13Testosterone (Sustanon)FDA Link
02/2024 - 08/2004
13EnzymesIBA
01/2021 - 03/2004
10Dexamethasone (Maxidex)FDA LinkGeneric
10/2023 - 06/2008
10MineralocorticoidsIBA
01/2023 - 05/2003
9Androgen Receptors (Androgen Receptor)IBA
12/2023 - 07/2010
9Adrenocorticotropic Hormone (ACTH)FDA Link
02/2017 - 08/2003
8Adrenal Cortex Hormones (Corticosteroids)IBA
01/2018 - 06/2008
7Glucose (Dextrose)FDA LinkGeneric
01/2023 - 03/2014
6Biomarkers (Surrogate Marker)IBA
03/2024 - 10/2008
6Steroid 21-Hydroxylase (21 Hydroxylase)IBA
11/2018 - 06/2004
5AldosteroneIBA
05/2024 - 04/2017
5Mitotane (Lysodren)FDA Link
10/2023 - 06/2012
417-alpha-Hydroxyprogesterone (17 Hydroxyprogesterone)IBA
01/2023 - 11/2004
4Insulin (Novolin)FDA Link
03/2022 - 02/2015
4abirateroneIBA
01/2022 - 02/2012
4Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA
10/2021 - 03/2012
4LipidsIBA
01/2021 - 02/2013
4Cosyntropin (Cortrosyn)FDA LinkGeneric
01/2020 - 02/2012
4Dehydroepiandrosterone SulfateIBA
01/2020 - 07/2006
4Triglycerides (Triacylglycerol)IBA
10/2019 - 05/2010
4Androstenedione (4 Androstene 3,17 dione)IBA
03/2019 - 03/2014
4Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA
04/2017 - 02/2010
4Cytochrome P-450 Enzyme System (Cytochrome P450)IBA
03/2013 - 03/2004
32- (1- (5- (cyclohexylcarbamoyl)- 6- propylsulfanylpyridin- 2- yl)- 3- piperidyl)acetic acidIBA
04/2024 - 01/2020
3SaltsIBA
01/2023 - 11/2017
3ReninIBA
01/2023 - 12/2012
3MethylprednisoloneFDA LinkGeneric
12/2017 - 06/2008
311-beta-Hydroxysteroid Dehydrogenase Type 1IBA
03/2011 - 08/2003
2Gonadal Steroid Hormones (Sex Hormones)IBA
02/2024 - 11/2017
2Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
01/2022 - 01/2019
2Mixed Function Oxygenases (Monooxygenases)IBA
10/2021 - 03/2013
2CytokinesIBA
01/2021 - 05/2014
2Estrogens (Estrogen)FDA Link
01/2021 - 03/2011
2NormetanephrineIBA
12/2019 - 03/2013
2Messenger RNA (mRNA)IBA
10/2019 - 02/2017
2Abiraterone AcetateIBA
08/2019 - 02/2012
2Proteins (Proteins, Gene)FDA Link
01/2019 - 01/2015
2Sex Hormone-Binding GlobulinIBA
01/2019 - 01/2018
2C-Reactive ProteinIBA
01/2019 - 12/2012

Therapy/Procedure

24Therapeutics
05/2024 - 05/2003
9Castration
01/2022 - 02/2012
7Adrenalectomy
10/2023 - 12/2016
6Critical Care (Surgical Intensive Care)
01/2018 - 06/2008
4Ovariectomy (Oophorectomy)
09/2012 - 11/2004
2Resuscitation
01/2021 - 04/2009